| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
Porcine artery elastin preparation reduces serum cholesterol level in rats
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| Autores: |
Liyanage, Ruvini
Nakamura, Yumi
Shimada, Ken-ichiro
Sekikawa, Mitsuo
Jayawardana, Barana Chaminda
Han, Kyu-Ho
Tomoko, Okada
Ohba, Kiyoshi
Takahata, Yoshihisa
Morimatsu, Fumiki
Fukushima, Michihiro
福島, 道広
島田, 謙一郎
関川, 三男
韓, 圭鎬
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| Data: |
2009-10
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| Ano: |
2009
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| Resumo: |
The effect of porcine artery elastin on serum cholesterol level was investigated in rats fed a cholesterol-free diet. Rats were fed for 4 weeks, with a diet (ED) containing 15% casein and 5% of porcine artery elastin in comparison with a diet (CD) containing 20% casein. The total serum and non-HDL-cholesterol concentrations were lower (P<0.001) in ED-fed group than the CD-fed group at the end of the experiment. Caecal propionate concentration and Bifidobacterium and Lactobacillus population were higher (P<0.05) in ED-fed group than the CD-fed group. The results of this study suggest that porcine artery elastin could be considered as a functional dietary protein with hypocholesterolaemic ability. Favourable amino acid composition and lysine derived cross links may at least be partially responsible for the hypocholesterolaemic ability of ED. Moreover, the higher caecal propionic acid concentration in the ED-fed group may have suppressed the cholesterol synthesis in the liver, and reduced the serum cholesterol level.
http://www.sciencedirect.com/science/journal/17564646
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/2681
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| Editor: |
Elsevier Ltd.
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| Formato: |
application/pdf
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| Direitos: |
Elsevier Ltd
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